TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

Non-amyloid, ubiquitinated cytoplasmic inclusions containing TDP-43 and its C-terminal fragments are pathological hallmarks of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder, and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). Importantly, TDP-43 mu...

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Detalhes bibliográficos
Main Authors: Johnson, Brian S., Snead, David, Lee, Jonathan J., McCaffery, J. Michael, Shorter, James, Gitler, Aaron D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740458/
https://ncbi.nlm.nih.gov/pubmed/19465477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.010264
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