TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis

See Fratta and Isaacs (doi:10.1093/brain/awy091) for a scientific commentary on this article. The RNA binding proteins TDP-43 (encoded by TARDBP) and hnRNP A1 (HNRNPA1) are each mutated in certain amyotrophic lateral sclerosis cases and are often mislocalized in cytoplasmic aggregates within motor n...

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Veröffentlicht in:Brain
Hauptverfasser: Deshaies, Jade-Emmanuelle, Shkreta, Lulzim, Moszczynski, Alexander J, Sidibé, Hadjara, Semmler, Sabrina, Fouillen, Aurélien, Bennett, Estelle R., Bekenstein, Uriya, Destroismaisons, Laurie, Toutant, Johanne, Delmotte, Quentin, Volkening, Kathryn, Stabile, Stéphanie, Aulas, Anaïs, Khalfallah, Yousra, Soreq, Hermona, Nanci, Antonio, Strong, Michael J, Chabot, Benoit, Vande Velde, Christine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5917749/
https://ncbi.nlm.nih.gov/pubmed/29562314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy062
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