TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis

See Fratta and Isaacs (doi:10.1093/brain/awy091) for a scientific commentary on this article. The RNA binding proteins TDP-43 (encoded by TARDBP) and hnRNP A1 (HNRNPA1) are each mutated in certain amyotrophic lateral sclerosis cases and are often mislocalized in cytoplasmic aggregates within motor n...

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Publicado no:Brain
Main Authors: Deshaies, Jade-Emmanuelle, Shkreta, Lulzim, Moszczynski, Alexander J, Sidibé, Hadjara, Semmler, Sabrina, Fouillen, Aurélien, Bennett, Estelle R., Bekenstein, Uriya, Destroismaisons, Laurie, Toutant, Johanne, Delmotte, Quentin, Volkening, Kathryn, Stabile, Stéphanie, Aulas, Anaïs, Khalfallah, Yousra, Soreq, Hermona, Nanci, Antonio, Strong, Michael J, Chabot, Benoit, Vande Velde, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5917749/
https://ncbi.nlm.nih.gov/pubmed/29562314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy062
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