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Chain length specificity for activation of cPLA(2)α by C1P: use of the dodecane delivery system to determine lipid-specific effects

Previously, our laboratory demonstrated that ceramide-1-phosphate (C1P) specifically activated group IVA cytosolic phospholipase A(2) (cPLA(2)α) in vitro. In this study, we investigated the chain length specificity of this interaction. C1P with an acyl-chain of ≥6 carbons efficiently activated cPLA(...

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Detalhes bibliográficos
Main Authors: Wijesinghe, Dayanjan S., Subramanian, Preeti, Lamour, Nadia F., Gentile, Luciana B., Granado, Maria H., Bielawska, Alicja, Szulc, Zdzislaw, Gomez-Munoz, Antonio, Chalfant, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739767/
https://ncbi.nlm.nih.gov/pubmed/19075030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800367-JLR200
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