Triglyceride alters lysosomal cholesterol ester metabolism in cholesteryl ester-laden macrophage foam cells

In late-stage atherosclerosis, much of the cholesterol in macrophage foam cells resides within enlarged lysosomes. Similarly, human macrophages incubated in vitro with modified LDLs contain significant amounts of lysosomal free cholesterol and cholesteryl ester (CE), which disrupts lysosomal functio...

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Main Authors: Ullery-Ricewick, Jody C., Cox, Brian E., Griffin, Evelyn E., Jerome, W. Gray
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739755/
https://ncbi.nlm.nih.gov/pubmed/19461120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800659-JLR200
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