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Triglyceride alters lysosomal cholesterol ester metabolism in cholesteryl ester-laden macrophage foam cells
In late-stage atherosclerosis, much of the cholesterol in macrophage foam cells resides within enlarged lysosomes. Similarly, human macrophages incubated in vitro with modified LDLs contain significant amounts of lysosomal free cholesterol and cholesteryl ester (CE), which disrupts lysosomal functio...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2739755/ https://ncbi.nlm.nih.gov/pubmed/19461120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800659-JLR200 |
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