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Lysosomal Cholesterol Accumulation Inhibits Subsequent Hydrolysis Of Lipoprotein Cholesteryl Ester

Human macrophages incubated for prolonged periods with mildly oxidized LDL (oxLDL) or cholesteryl ester-rich lipid dispersions (DISP) accumulate free and esterified cholesterol within large, swollen lysosomes similar to those in foam cells of atherosclerosis. The cholesteryl ester (CE) accumulation...

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Detalhes bibliográficos
Main Authors: Jerome, W. Gray, Cox, Brian E., Griffin, Evelyn E., Ullery, Jody C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837357/
https://ncbi.nlm.nih.gov/pubmed/18312718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1431927608080069
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