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TGR5-mediated bile acid sensing controls glucose homeostasis
TGR5 is a G-protein coupled receptor expressed in brown adipose tissue and muscle where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- and loss-of function studies in vivo, we show...
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| Main Authors: | , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2739652/ https://ncbi.nlm.nih.gov/pubmed/19723493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.08.001 |
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