TGR5-mediated bile acid sensing controls glucose homeostasis

TGR5 is a G-protein coupled receptor expressed in brown adipose tissue and muscle where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- and loss-of function studies in vivo, we show...

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Main Authors: Thomas, Charles, Gioiello, Antimo, Noriega, Lilia, Strehle, Axelle, Oury, Julien, Rizzo, Giovanni, Macchiarulo, Antonio, Yamamoto, Hiroyasu, Mataki, Chikage, Pruzanski, Mark, Pellicciari, Roberto, Auwerx, Johan, Schoonjans, Kristina
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739652/
https://ncbi.nlm.nih.gov/pubmed/19723493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.08.001
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