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Effect of Active-site Mutation at Asn67 on the Proton Transfer Mechanism of Human Carbonic Anhydrase II
The rate-limiting proton transfer (PT) event in the site-specific mutant N67L of human carbonic anhydrase II (HCA II) has been examined by kinetic, x-ray, and simulation approaches. The x-ray crystallography, which were previously reported, and molecular dynamics (MD) simulations indicate that the p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2739621/ https://ncbi.nlm.nih.gov/pubmed/19634894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901037u |
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