Statistical Use of Argonaute Expression and RISC Assembly in microRNA Target Identification

MicroRNAs (miRNAs) posttranscriptionally regulate targeted messenger RNAs (mRNAs) by inducing cleavage or otherwise repressing their translation. We address the problem of detecting m/miRNA targeting relationships in homo sapiens from microarray data by developing statistical models that are motivat...

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Bibliografiske detaljer
Main Authors: Stanhope, Stephen A., Sengupta, Srikumar, den Boon, Johan, Ahlquist, Paul, Newton, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739424/
https://ncbi.nlm.nih.gov/pubmed/19779550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000516
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