Multidomain Convergence of Argonaute During RISC Assembly Correlates with the Formation of Internal Water Clusters

Despite the relevance of Argonaute proteins in RNA silencing, little is known about the structural steps of small-RNA loading to form RNA-induced silencing complexes (RISCs). We report the 1.9 Å crystal structure of human Argonaute4 with guide RNA. Comparison with the previously determined apo struc...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Park, Mi Seul, Araya-Secchi, Raul, Brackbill, James A., Phan, Hong-Duc, Kehling, Audrey C., El-Wahab, Ekram W. Abd, Dayeh, Daniel M., Sotomayor, Marcos, Nakanishi, Kotaro
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707842/
https://ncbi.nlm.nih.gov/pubmed/31324450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.011
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados