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Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNA

RNA interfering is a eukaryote-specific gene silencing by 20∼23-nucleotide (nt) microRNAs and small interfering RNAs that recruit Argonaute proteins to complementary RNAs for degradation. In humans, Argonaute2 (AGO2) has been known as the only slicer while Argonaute3 (AGO3) barely cleaves RNAs. Ther...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Park, Mi Seul, Sim, GeunYoung, Kehling, Audrey C., Nakanishi, Kotaro
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682322/
https://ncbi.nlm.nih.gov/pubmed/33122430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015026117
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