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A bacterial Argonaute with noncanonical guide RNA specificity

Eukaryotic Argonaute proteins induce gene silencing by small RNA-guided recognition and cleavage of mRNA targets. Although structural similarities between human and prokaryotic Argonautes are consistent with shared mechanistic properties, sequence and structure-based alignments suggested that Argona...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kaya, Emine, Doxzen, Kevin W., Knoll, Kilian R., Wilson, Ross C., Strutt, Steven C., Kranzusch, Philip J., Doudna, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839417/
https://ncbi.nlm.nih.gov/pubmed/27035975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524385113
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