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Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas

The tumor predisposition disorder Neurofibromatosis type I (NF1) is one of the most common genetic disorders of the nervous system. It is caused by mutation in the Nf1 tumor suppressor gene, which encodes a GTPase Activating Protein (GAP) that negatively regulates p21-RAS. The development of maligna...

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書誌詳細
主要な著者: Le, Lu Q., Shipman, Tracey, Burns, Dennis K., Parada, Luis F.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737469/
https://ncbi.nlm.nih.gov/pubmed/19427294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.03.017
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