Minimizing off-target effects by using diced siRNAs for RNA interference

Microarray studies have shown that individual synthetic small interfering RNAs (siRNAs) can have substantial off-target effects. Pools of siRNAs, produced by incubation of dsRNAs with recombinant Dicer or RNase III, can also be used to silence genes. Here we show that diced siRNA pools are highly co...

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Библиографические подробности
Главные авторы: Myers, Jason W, Chi, Jen-Tsan, Gong, Delquin, Schaner, Marci E, Brown, Patrick O, Ferrell, James E
Формат: Artigo
Язык:Inglês
Опубликовано: Library Publishing Media 2006
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737221/
https://ncbi.nlm.nih.gov/pubmed/19771225
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