TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells

Stimulation of Toll-like receptors (TLRs) on macrophages and dendritic cells (DCs) by pathogen-derived products induces the production of cytokines, which play an important role in immune responses. Here, we investigated the role of the TPL-2 signaling pathway in TLR induction of interferon-β (IFN-β...

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Bibliographische Detailangaben
Hauptverfasser: Kaiser, Frank, Cook, Dorthe, Papoutsopoulou, Stamatia, Rajsbaum, Ricardo, Wu, Xuemei, Yang, Huei-Ting, Grant, Susan, Ricciardi-Castagnoli, Paola, Tsichlis, Philip N., Ley, Steven C., O'Garra, Anne
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2009
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737152/
https://ncbi.nlm.nih.gov/pubmed/19667062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091059
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