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Systematic Exploration of Active Site Mutations on Human Deoxycytidine Kinase Substrate Specificity

Human deoxycytidine kinase (dCK) is responsible for the phosphorylation of a number of clinically important nucleoside analogue prodrugs in addition to its natural substrates, 2′-deoxycytidine, 2′-deoxyguanosine, and 2′-deoxyadenosine. To improve the low catalytic activity and tailor the substrate s...

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Detalhes bibliográficos
Main Authors: Iyidogan, Pinar, Lutz, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736870/
https://ncbi.nlm.nih.gov/pubmed/18361501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800157e
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