Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux

Alterations in the autophagic pathway are associated with the onset and progression of various diseases. However, despite the therapeutic potential for pharmacological modulators of autophagic flux, few such compounds have been characterised. Here we show that clomipramine, an FDA-approved drug long...

Full description

Saved in:
Bibliographic Details
Main Authors: Rossi, Mario, Munarriz, Eliana Rosa, Bartesaghi, Stefano, Milanese, Marco, Dinsdale, David, Guerra-Martin, Maria Azucena, Bampton, Edward T. W., Glynn, Paul, Bonanno, Giambattista, Knight, Richard A., Nicotera, Pierluigi, Melino, Gerry
Format: Artigo
Language:Inglês
Published: Company of Biologists 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736865/
https://ncbi.nlm.nih.gov/pubmed/19706685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.048181
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items