Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux

Alterations in the autophagic pathway are associated with the onset and progression of various diseases. However, despite the therapeutic potential for pharmacological modulators of autophagic flux, few such compounds have been characterised. Here we show that clomipramine, an FDA-approved drug long...

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Detalhes bibliográficos
Main Authors: Rossi, Mario, Munarriz, Eliana Rosa, Bartesaghi, Stefano, Milanese, Marco, Dinsdale, David, Guerra-Martin, Maria Azucena, Bampton, Edward T. W., Glynn, Paul, Bonanno, Giambattista, Knight, Richard A., Nicotera, Pierluigi, Melino, Gerry
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736865/
https://ncbi.nlm.nih.gov/pubmed/19706685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.048181
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