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Increased O-GlcNAc Causes Disrupted Lens Fiber Cell Differentiation and Cataracts
Diminished proteolytic functionality in the lens may cause cataracts. We have reported that O-GlcNAc is an endogenous inhibitor of the proteasome. We hypothesize that in the lens there is a cause-and-effect relationship between proteasome inhibition by O-GlcNAc, and cataract formation. To demonstrat...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2736685/ https://ncbi.nlm.nih.gov/pubmed/19577582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.06.132 |
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