Increased O-GlcNAc Causes Disrupted Lens Fiber Cell Differentiation and Cataracts

Diminished proteolytic functionality in the lens may cause cataracts. We have reported that O-GlcNAc is an endogenous inhibitor of the proteasome. We hypothesize that in the lens there is a cause-and-effect relationship between proteasome inhibition by O-GlcNAc, and cataract formation. To demonstrat...

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Hlavní autoři: Wang, Kai, Ho, Shiuh-Rong, Mao, Weiming, Huang, Ping, Zhang, Fengxue, Schwiebert, Erik M., Kudlow, Jeffrey E., Paterson, Andrew J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736685/
https://ncbi.nlm.nih.gov/pubmed/19577582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.06.132
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