O-GlcNAc Integrates the Proteasome and Transcriptome To Regulate Nuclear Hormone Receptors

Mechanisms controlling nuclear hormone receptors are a central question to mammalian developmental and disease processes. Herein, we show that a subtle increase in O-GlcNAc levels inhibits activation of nuclear hormone receptors. In vivo, increased levels of O-GlcNAc impair estrogen receptor activat...

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Detalhes bibliográficos
Main Authors: Bowe, Damon B., Sadlonova, Andrea, Toleman, Clifford A., Novak, Zdenek, Hu, Yong, Huang, Ping, Mukherjee, Shibani, Whitsett, Timothy, Frost, Andra R., Paterson, Andrew J., Kudlow, Jeffrey E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636782/
https://ncbi.nlm.nih.gov/pubmed/16966374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01053-06
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