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Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

Protein damage contributes prominently to cellular aging. To address whether this occurs at a specific period during aging or accumulates gradually, we monitored the biochemical, cellular, and physiological properties of folding sensors expressed in different tissues of C. elegans. We observed the a...

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Bibliografiske detaljer
Main Authors: Ben-Zvi, Anat, Miller, Elizabeth A., Morimoto, Richard I.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736453/
https://ncbi.nlm.nih.gov/pubmed/19706382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902882106
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