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The Schizosaccharomyces pombe Hsp104 Disaggregase Is Unable to Propagate the [PSI (+)] Prion

The molecular chaperone Hsp104 is a crucial factor in the acquisition of thermotolerance in yeast. Under stress conditions, the disaggregase activity of Hsp104 facilitates the reactivation of misfolded proteins. Hsp104 is also involved in the propagation of fungal prions. For instance, the well-char...

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Detalhes bibliográficos
Main Authors: Sénéchal, Patrick, Arseneault, Geneviève, Leroux, Alexandre, Lindquist, Susan, Rokeach, Luis A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736384/
https://ncbi.nlm.nih.gov/pubmed/19759825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006939
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