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New Sources of Chemical Diversity Inspired by Biosynthesis: Rational Design of a Potent Epothilone Analogue

[Image: see text] A concise total synthesis of S-14-methoxy-epothilone D has been accomplished. S-14-Methoxy-epothilone D represents a conceptually novel example of polyketide analogue design based on an alternative biogenetic pattern of extender units. The significant biological activity observed f...

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Autori principali: Frein, Jeffrey D., Taylor, Richard E., Sackett, Dan L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736359/
https://ncbi.nlm.nih.gov/pubmed/19572566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol900971r
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