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Linking the p53 tumor suppressor pathway to somatic cell reprogramming

Reprogramming somatic cells to induced pluripotent stem (iPS) cells has been accomplished by expressing pluripotency factors and oncogenes1–8, but the low frequency and tendency to induce malignant transformation9 compromise the clinical utility of this powerful approach. We address both issues by i...

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Bibliographische Detailangaben
Hauptverfasser: Kawamura, Teruhisa, Suzuki, Jotaro, Wang, Yunyuan V., Menendez, Sergio, Morera, Laura Batlle, Raya, Angel, Wahl, Geoffrey M., Belmonte, Juan Carlos Izpisúa
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735889/
https://ncbi.nlm.nih.gov/pubmed/19668186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08311
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