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Linking the p53 tumor suppressor pathway to somatic cell reprogramming
Reprogramming somatic cells to induced pluripotent stem (iPS) cells has been accomplished by expressing pluripotency factors and oncogenes1–8, but the low frequency and tendency to induce malignant transformation9 compromise the clinical utility of this powerful approach. We address both issues by i...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2735889/ https://ncbi.nlm.nih.gov/pubmed/19668186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08311 |
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