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Enhanced Excitation-Coupled Calcium Entry in Myotubes Expressing Malignant Hyperthermia Mutation R163C Is Attenuated by Dantrolene

Dantrolene is the drug of choice for the treatment of malignant hyperthermia (MH) and is also useful for treatment of spasticity or muscle spasms associated with several clinical conditions. The current study examines the mechanisms of dantrolene's action on skeletal muscle and shows that one o...

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Detalhes bibliográficos
Main Authors: Cherednichenko, Gennady, Ward, Chris W., Feng, Wei, Cabrales, Elaine, Michaelson, Luke, Samso, Montserrat, López, José R., Allen, Paul D., Pessah, Isaac N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735873/
https://ncbi.nlm.nih.gov/pubmed/18171728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.043299
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