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A malignant hyperthermia–inducing mutation in RYR1 (R163C): alterations in Ca(2+) entry, release, and retrograde signaling to the DHPR
Bidirectional signaling between the sarcolemmal L-type Ca(2+) channel (1,4-dihydropyridine receptor [DHPR]) and the sarcoplasmic reticulum (SR) Ca(2+) release channel (type 1 ryanodine receptor [RYR1]) of skeletal muscle is essential for excitation–contraction coupling (ECC) and is a well-understood...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2888056/ https://ncbi.nlm.nih.gov/pubmed/20479110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200910328 |
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