Functional and Biochemical Properties of Ryanodine Receptor Type 1 Channels from Heterozygous R163C Malignant Hyperthermia-Susceptible Mice

Mutations in ryanodine receptor type 1 (RyR1) confer malignant hyperthermia susceptibility. How inherent impairments in Ca(2+) channel regulation affect skeletal muscle function in myotubes and adult fibers under basal (nontriggering) conditions are not understood. Myotubes, adult flexor digitorum b...

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Main Authors: Feng, Wei, Barrientos, Genaro C., Cherednichenko, Gennady, Yang, Tianzhong, Padilla, Isela T., Truong, Kim, Allen, Paul D., Lopez, José R., Pessah, Isaac N.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061367/
https://ncbi.nlm.nih.gov/pubmed/21156754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.067959
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