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Romidepsin inhibits Ras-dependent growth transformation of NIH 3T3 fibroblasts and RIE-1 epithelial cells independently of Ras signaling inhibition

BACKGROUND: Despite intensive effort, currently no effective anti-Ras therapies have successfully reached clinical application. Previous studies suggest that the histone deacetylatse (HDAC) inhibitor romidepsin, which is currently in clinical trials for the treatment of multiple malignancies, can bl...

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Bibliografiske detaljer
Main Authors: Hanker, Ariella B, Healy, Kevin D, Nichols, Jean, Der, Channing J
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735739/
https://ncbi.nlm.nih.gov/pubmed/19682393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-2187-4-5
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