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A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells

Leukemia associated Rho guanine nucleotide exchange factor (LARG) activates RhoA in response to signals received by specific classes of cell surface receptors. The catalytic core of LARG is a Dbl homology (DH) domain whose activity is modulated by an adjacent pleckstrin homology (PH) domain. In this...

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Detalhes bibliográficos
Main Authors: Aittaleb, Mohamed, Gao, Guang, Evelyn, Chris R., Neubig, Richard R., Tesmer, John J. G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735620/
https://ncbi.nlm.nih.gov/pubmed/19560536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2009.06.003
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