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A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells
Leukemia associated Rho guanine nucleotide exchange factor (LARG) activates RhoA in response to signals received by specific classes of cell surface receptors. The catalytic core of LARG is a Dbl homology (DH) domain whose activity is modulated by an adjacent pleckstrin homology (PH) domain. In this...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2735620/ https://ncbi.nlm.nih.gov/pubmed/19560536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2009.06.003 |
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