Hypoxia inhibits maturation and trafficking of HERG K(+) channel protein: Role of Hsp90 and ROS

We previously reported that reactive oxygen species (ROS) generated during hypoxia decrease hERG current density and protein expression in HEK cells stably expressing hERG protein. In the present study, we investigated the molecular mechanisms involved in hypoxia induced downregulation of hERG prote...

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Detaylı Bibliyografya
Asıl Yazarlar: Nanduri, Jayasri, Bergson, Pamela, Wang, Ning, Ficker, Eckhard, Prabhakar, Nanduri R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735591/
https://ncbi.nlm.nih.gov/pubmed/19654002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.07.149
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