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Optimized Bacterial Expression and Purification of the c-Src Catalytic Domain for Solution NMR Studies
Progression of a host of human cancers is associated with elevated levels of expression and catalytic activity of the Src family of tyrosine kinases (SFKs), making them key therapeutic targets. Even with the availability of multiple crystal structures of active and inactive forms of the SFK catalyti...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2735562/ https://ncbi.nlm.nih.gov/pubmed/19399371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-009-9318-y |
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