Allosteric Signaling in the Biotin Repressor Occurs via Local Folding Coupled to Global Dampening of Protein Dynamics

The biotin repressor is an allosterically regulated site-specific DNA binding protein. Binding of the small ligand, bio-5'-AMP, activates repressor dimerization, which is a prerequisite to DNA binding. Multiple disorder-to-order transitions, some of which are known to be important for the funct...

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Huvudupphovsmän: Laine, Olli, Streaker, Emily D., Nabavi, Maryam, Fenselau, Catherine C., Beckett, Dorothy
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735192/
https://ncbi.nlm.nih.gov/pubmed/18586268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.018
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