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Allosteric Signaling in the Biotin Repressor Occurs via Local Folding Coupled to Global Dampening of Protein Dynamics
The biotin repressor is an allosterically regulated site-specific DNA binding protein. Binding of the small ligand, bio-5'-AMP, activates repressor dimerization, which is a prerequisite to DNA binding. Multiple disorder-to-order transitions, some of which are known to be important for the funct...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2008
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2735192/ https://ncbi.nlm.nih.gov/pubmed/18586268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.018 |
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