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Corepressor-induced organization and assembly of the biotin repressor: A model for allosteric activation of a transcriptional regulator

The Escherichia coli biotin repressor binds to the biotin operator to repress transcription of the biotin biosynthetic operon. In this work, a structure determined by x-ray crystallography of a complex of the repressor bound to biotin, which also functions as an activator of DNA binding by the bioti...

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Detalles Bibliográficos
Main Authors: Weaver, Larry H., Kwon, Keehwan, Beckett, Dorothy, Matthews, Brian W.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC33419/
https://ncbi.nlm.nih.gov/pubmed/11353844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111128198
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