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Binding specificity and the ligand dissociation process in the E. coli biotin holoenzyme synthetase
The binding of the Escherichia coli biotin holoenzyme synthetase to the two ligands, biotin and bio-5`-AMP, is coupled to disorder-to-order transitions in the protein. In the structure of the biotin complex, a "glycine-rich" loop that is disordered in the apo-enzyme is folded over the liga...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373468/ https://ncbi.nlm.nih.gov/pubmed/11847279 |
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