Genetic Variation in the Proximal Promoter of ABC and SLC Superfamilies: Liver and Kidney Specific Expression and Promoter Activity Predict Variation

Membrane transporters play crucial roles in the cellular uptake and efflux of an array of small molecules including nutrients, environmental toxins, and many clinically used drugs. We hypothesized that common genetic variation in the proximal promoter regions of transporter genes contribute to obser...

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Main Authors: Hesselson, Stephanie E., Matsson, Pär, Shima, James E., Fukushima, Hisayo, Yee, Sook Wah, Kobayashi, Yuya, Gow, Jason M., Ha, Connie, Ma, Benjamin, Poon, Annie, Johns, Susan J., Stryke, Doug, Castro, Richard A., Tahara, Harunobu, Choi, Ji Ha, Chen, Ligong, Picard, Nicolas, Sjödin, Elin, Roelofs, Maarke J. E., Ferrin, Thomas E., Myers, Richard, Kroetz, Deanna L., Kwok, Pui-Yan, Giacomini, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735003/
https://ncbi.nlm.nih.gov/pubmed/19742321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006942
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