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Endothelial-specific expression of mitochondrial thioredoxin promotes ischemia-mediated arteriogenesis and angiogenesis
OBJECTIVE: Thioredoxin-2 (Trx2),a major antioxidant protein in mitochondria, enhances nitric oxide bioavailability and inhibits ASK1-dependent apoptosis in endothelial cells (EC). However, the in vivo role of Trx2 in angiogenesis has not been defined. Here we used endothelial cell (EC)-specific tran...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734510/ https://ncbi.nlm.nih.gov/pubmed/19150880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.108.180349 |
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