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Endothelial-specific expression of mitochondrial thioredoxin promotes ischemia-mediated arteriogenesis and angiogenesis

OBJECTIVE: Thioredoxin-2 (Trx2),a major antioxidant protein in mitochondria, enhances nitric oxide bioavailability and inhibits ASK1-dependent apoptosis in endothelial cells (EC). However, the in vivo role of Trx2 in angiogenesis has not been defined. Here we used endothelial cell (EC)-specific tran...

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Bibliografiska uppgifter
Huvudupphovsmän: Dai, Shengchuan, He, Yun, Zhang, Haifeng, Yu, Luyang, Wan, Ting, Xu, Zhe, Jones, Dennis, Chen, Hong, Min, Wang
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734510/
https://ncbi.nlm.nih.gov/pubmed/19150880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.108.180349
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