Endothelial-Specific Expression of Mitochondrial Thioredoxin Improves Endothelial Cell Function and Reduces Atherosclerotic Lesions

The function of the mitochondrial antioxidant system thioredoxin (Trx2) in vasculature is not understood. By using endothelial cell (EC)-specific transgenesis of the mitochondrial form of the thioredoxin gene in mice (Trx2 TG), we show the critical roles of Trx2 in regulating endothelium functions....

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Библиографические подробности
Главные авторы: Zhang, Haifeng, Luo, Yan, Zhang, Wei, He, Yun, Dai, Shengchuan, Zhang, Rong, Huang, Yan, Bernatchez, Pascal, Giordano, Frank J., Shadel, Gerald, Sessa, William C., Min, Wang
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2007
Предметы:
Regular Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864879/
https://ncbi.nlm.nih.gov/pubmed/17322393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060960
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