Endothelial-Specific Expression of Mitochondrial Thioredoxin Improves Endothelial Cell Function and Reduces Atherosclerotic Lesions

The function of the mitochondrial antioxidant system thioredoxin (Trx2) in vasculature is not understood. By using endothelial cell (EC)-specific transgenesis of the mitochondrial form of the thioredoxin gene in mice (Trx2 TG), we show the critical roles of Trx2 in regulating endothelium functions....

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Bibliografiske detaljer
Main Authors: Zhang, Haifeng, Luo, Yan, Zhang, Wei, He, Yun, Dai, Shengchuan, Zhang, Rong, Huang, Yan, Bernatchez, Pascal, Giordano, Frank J., Shadel, Gerald, Sessa, William C., Min, Wang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2007
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864879/
https://ncbi.nlm.nih.gov/pubmed/17322393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060960
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