AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice

ASK1-interacting protein-1 (AIP1), a recently identified member of the Ras GTPase-activating protein family, is highly expressed in vascular ECs and regulates EC apoptosis in vitro. However, its function in vivo has not been established. To study this, we generated AIP1-deficient mice (KO mice). Alt...

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Detalhes bibliográficos
Main Authors: Zhang, Haifeng, He, Yun, Dai, Shengchuan, Xu, Zhe, Luo, Yan, Wan, Ting, Luo, Dianhong, Jones, Dennis, Tang, Shibo, Chen, Hong, Sessa, William C., Min, Wang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575835/
https://ncbi.nlm.nih.gov/pubmed/19033661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36168
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