Evidence for endogenous formation of N′-nitrosonornicotine in some long-term nicotine patch users

INTRODUCTION: Nitrosation of nicotine or its metabolites in the human body could lead to formation of the 2 carcinogenic tobacco-specific nitrosamines—N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). METHODS: We investigated the possibility of endogenous formatio...

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Autores principales: Stepanov, Irina, Carmella, Steven G., Han, Shaomei, Pinto, Angela, Strasser, Andrew A., Lerman, Caryn, Hecht, Stephen S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2009
Materias:
Original Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734288/
https://ncbi.nlm.nih.gov/pubmed/19246447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ntr/ntn004
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