Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel

Chromosome rearrangement, a hallmark of cancer, has profound effects on carcinogenesis and tumor phenotype. We used a panel of 60 human cancer cell lines (the NCI-60) as a model system to identify relationships among DNA copy number, mRNA expression level, and drug sensitivity. For each of 64 cancer...

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Autores principales: Bussey, Kimberly J., Chin, Koei, Lababidi, Samir, Reimers, Mark, Reinhold, William C., Kuo, Wen-Lin, Gwadry, Fuad, Ajay, Kouros-Mehr, Hosein, Fridlyand, Jane, Jain, Ajay, Collins, Colin, Nishizuka, Satoshi, Tonon, Giovanni, Roschke, Anna, Gehlhaus, Kristen, Kirsch, Ilan, Scudiero, Dominic A., Gray, Joe W., Weinstein, John N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733874/
https://ncbi.nlm.nih.gov/pubmed/16648555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-05-0155
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