Chromosomal Instability Is Associated with Higher Expression of Genes Implicated in Epithelial-Mesenchymal Transition, Cancer Invasiveness, and Metastasis and with Lower Expression of Genes Involved in Cell Cycle Checkpoints, DNA Repair, and Chromatin Maintenance

Chromosomal instability—a hallmark of epithelial cancers—is an ongoing process that results in aneuploidy and karyotypic heterogeneity of a cancer cell population. Previously, we stratified cancer cell lines in the NCI-60 drug discovery panel based on their karyotypic complexity and heterogeneity. U...

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Bibliographic Details
Main Authors: Roschke, Anna V, Glebov, Oleg K, Lababidi, Samir, Gehlhaus, Kristen S, Weinstein, John N, Kirsch, Ilan R
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570598/
https://ncbi.nlm.nih.gov/pubmed/18953431
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