Functional Characterization and Structural Modeling of Obesity Associated Mutations in the Melanocortin 4 Receptor

Mutations in the melanocortin 4 receptor (MC4R) gene are the most common known cause of monogenic human obesity. The MC4R gene was sequenced in 2000 subjects with severe early-onset obesity. We detected seven different nonsense and 19 nonsynonymous mutations in a total of 94 probands, some of which...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Tan, Karen, Pogozheva, Irina D., Yeo, Giles S. H., Hadaschik, Dirk, Keogh, Julia M., Haskell-Leuvano, Carrie, O'Rahilly, Stephen, Mosberg, Henry I., Farooqi, I. Sadaf
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732289/
https://ncbi.nlm.nih.gov/pubmed/18801902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0721
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker